Combodart 0.5mg/0.4mg Capsules


Combodart: Dual-action capsules.

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Combodart 0.5mg/0.4mg Capsules - Rightangled

Quick view Summary

  • Type of medicine

    Treatment for benign prostatic hyperplasia (BPH)

  • Effective within

    Varies; Consult your doctor for personalized information

  • Works by

    reduce the size of the prostate and improve urinary flow.

  • Active ingredient

    Dutasteride (0.5 mg) and Tamsulosin Hydrochloride (0.4 mg)

  • Strength

    0.5 mg dutasteride + 0.4 mg tamsulosin hydrochloride per capsule

  • Common side effects

    - Impotence - Decreased sex drive - Difficulty with ejaculation - Breast enlargement or tenderness - Dizziness - Heart failure (less common) - Low blood pressure (less common) - Skin reactions (rare) - Other side effects (consult your doctor)

  • Generic


  • Use with alcohol

    Avoid excessive alcohol consumption while taking Combodart; consult your doctor

Combodart 0.5mg/0.4mg Capsules


Combodart is a prescription medication used to treat symptoms of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). The active ingredients in Combodart are dutasteride and tamsulosin, which work together to relax the muscles in the prostate and bladder neck, improving urinary flow and reducing symptoms such as weak urine stream, difficulty starting urination, and frequent urination. Combodart is taken orally, typically once a day. It is important to take Combodart exactly as prescribed by a healthcare provider and not to stop taking the medication suddenly, as this can cause symptoms to worsen.


It's important to follow your doctor's instructions when taking Combodart. The recommended dose is one capsule taken daily, 30 minutes after the same meal each day. Swallow the capsule whole with water and do not chew or break it open. Consistency in taking Combodart is crucial for effective results.


Combodart 0.5mg/0.4mg Capsules contain a synergistic combination of two active ingredients: dutasteride and tamsulosin. These ingredients work in tandem to address specific conditions related to the prostate gland, offering a comprehensive approach to treatment.
Dutasteride, present at a dosage of 0.5mg in each capsule, is a synthetic 4-azasteroid compound. It functions as a dual inhibitor of the 5α-reductase enzyme, specifically Type I and Type II isoforms. By inhibiting this enzyme, dutasteride effectively reduces the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen that contributes to the enlargement of the prostate gland in conditions such as benign prostatic hyperplasia (BPH). The inhibition of DHT production helps mitigate prostate enlargement, subsequently alleviating associated urinary symptoms.
Tamsulosin, found at a dosage of 0.4mg in each capsule, is an alpha1-adrenoceptor antagonist. It acts selectively on alpha1A and alpha1D receptors primarily located in the prostate gland, prostatic capsule, and bladder neck. By blocking these receptors, tamsulosin relaxes the smooth muscle within these areas. This relaxation results in improved urinary flow and reduced obstruction, which commonly occurs due to prostate enlargement. Tamsulosin's action aids in relieving lower urinary tract symptoms (LUTS) associated with conditions like BPH.

Side effects

As with any medication, Combodart may cause side effects in some individuals. Common side effects may include impotence, decreased sex drive, difficulty with ejaculation, breast enlargement, and dizziness. While most side effects are mild and temporary, it's important to contact your doctor if you experience any unusual or severe symptoms. Serious side effects are rare but may include heart failure, low blood pressure, skin reactions, and more. If you notice any signs of an allergic reaction, such as skin rash or swelling, seek medical attention immediately.


Before taking Combodart, inform your doctor of any existing health conditions or medications you are currently taking. Combodart may interact with certain medications, including PDE5 inhibitors and others. It's crucial to inform your doctor if you have liver problems, kidney issues, or if you are undergoing cataract surgery. Women, children, and adolescents should not handle leaking Combodart capsules, as the active ingredients can be absorbed through the skin.

Patient information leaflet

Download patient information leaflet (PIL) on the link below:


Can Combodart be used to treat prostate cancer?

No, Combodart is specifically designed to treat benign prostatic hyperplasia (BPH), a noncancerous enlargement of the prostate gland. It is not intended for the treatment of prostate cancer.

Can I take Combodart if I have a history of heart problems?

Before taking Combodart, it's important to inform your doctor of any existing health conditions, including heart problems. Combodart may interact with other medications, and your doctor will determine if it's safe for you based on your medical history.

Is there a risk of fertility issues while taking Combodart?

Combodart may affect sperm count, semen volume, and sperm motility, which could potentially impact fertility. If you are planning to have a child or are concerned about fertility, discuss your options with your doctor.

Can Combodart be taken with other medications for erectile dysfunction?

Combodart can interact with medications like PDE5 inhibitors (used to treat erectile dysfunction). It's important to inform your doctor about all the medications you are taking to avoid potential interactions.

Are there any dietary restrictions while taking Combodart?

While there are no specific dietary restrictions, it's recommended to take Combodart 30 minutes after the same meal each day. This consistency can help ensure optimal absorption and effectiveness of the medication.

Medically reviewed and published

This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead |

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